This unit introduces learners to thalassaemia, a blood disorder caused by mutations in the HBB gene, which prevent the production of normal hemoglobin. Students will first discover what thalassaemia is and how it affects the body. They will then explore how gene therapy — using tools such as CRISPR-Cas9 — can repair or replace faulty DNA, offering the possibility of a cure.
The unit follows the Explore – Execute – Enhance methodology:
- Explore: Building a foundation of knowledge about thalassaemia and gene therapy.
- Execute: Using Augmented Reality simulations and hands-on exercises to practice “correcting” faulty genes.
- Enhance: Reflecting on advanced applications, ethical debates, and the future of genetic therapies.
Created by CEIPES Partners